Keowee Hydro Station
- Capacity: 158 megawatts
- Location: Pickens County, South Carolina
- Commercial Date: 1971
Keowee Hydro Station is a two-unit facility located in Pickens County, S.C. Lake Keowee was the first lake developed as part of Duke Energy's Keowee-Toxaway Complex. The complex includes the Oconee Nuclear Station and the Keowee, Jocassee and Bad Creek hydroelectric stations.