Lee Steam Station
- Capacity: 370 megawatts
- Location: Anderson County, South Carolina
- Commercial Date: 1951

Lee Steam Station is a three-unit coal-fired generating facility located on the Saluda River in Anderson County, South Carolina. The facility is named for Duke Power co-founder William States Lee and is Duke Energy’s only coal-fired generating facility in South Carolina. Lee operates as a cycling station to supplement supply when electricity demand is highest.
In 2004, Duke Energy entered into a voluntary agreement with the South Carolina Department of Health & Environmental Control to install additional nitrogen oxide emission controls at Lee Steam Station. The controls support the Greenville/Spartanburg/Anderson Early Action Compact to reduce smog-forming emissions in Upstate South Carolina.
In January 2007, Duke Energy began commercial operation of two new 42-megawatt combustion turbine units. The two units replaced three existing combustion turbine units that were decommissioned at that time.
